3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester

Base Information

• Chemical Name: 3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester
• CAS No.: 107704-31-4
• Molecular Formula: C₂₈H₃₂N₂O₄
• Molecular Weight: 460.573
• Mol file: 107704-31-4.mol

Synonyms:3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester

Chemical Property of 3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester

There total 5 articles about 3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tryptamine (61-54-1) + 7-Benzyloxy-4,4-bis(ethoxycarbonyl)heptanal (107704-30-3) → 3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester (107704-31-4)

Guidance literature:

With acetic acid; for 7h; Heating;

DOI:10.1016/S0040-4020(01)86686-2

Reference yield: 62.0%

1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol (128432-25-7) → 3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester (107704-31-4)

Guidance literature:

With potassium carbonate; In ethanol; for 90h;

DOI:10.1016/S0040-4020(01)86686-2

Reference yield:

Ethyl 5-benzyloxy-2-(ethoxycarbonyl)pentanoate (82258-55-7) → 3-(3-Benzyloxypropyl)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-3-carbonsaeureethylester (107704-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Na / 1) ethanol, 5 deg C, 2) 1.5 h, r.t.

2: 97 percent / glacial acetic acid / 7 h / Heating

With sodium; acetic acid;

DOI:10.1016/S0040-4020(01)86686-2

upstream raw materials:

tryptamine

7-Benzyloxy-4,4-bis(ethoxycarbonyl)heptanal

1-<6-Benzyloxy-3,3-bis(ethoxycarbonyl)-hexyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol

Ethyl 5-benzyloxy-2-(ethoxycarbonyl)pentanoate

Downstream raw materials:

3-(3-Benzyloxypropyl)-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizin-4-on

9-(3-Benzyloxy-propyl)-6,7,8,9,10,11,12,13-octahydro-5H-7,13-diaza-cyclodeca[a]indene-12-carboxylic acid

3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-carbonsaeuemethylester

3-Benzyloxycarbonyl-5-(3-benzyloxypropyl)-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>indol-8-ol