3-(3-FLUORO-BENZYLOXY)-PHENYLAMINE

Base Information

• Chemical Name: 3-(3-FLUORO-BENZYLOXY)-PHENYLAMINE
• CAS No.: 865611-14-9
• Molecular Formula: C₁₃H₁₂FNO
• Molecular Weight: 217.243
• Mol file: 865611-14-9.mol

Synonyms:3-[(3-fluorobenzyl)oxy]aniline

Chemical Property of 3-(3-FLUORO-BENZYLOXY)-PHENYLAMINE

Chemical Property:

• Boiling Point: 359.9±22.0 °C(Predicted)
• PKA: 4.10±0.10(Predicted)
• Density: 1.202±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

3-[(3-fluorophenyl)methoxy]aniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

Useful:

Technology Process of 3-(3-FLUORO-BENZYLOXY)-PHENYLAMINE

There total 5 articles about 3-(3-FLUORO-BENZYLOXY)-PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

1-fluoro-3-((3-nitrophenoxy)methyl)benzene (865611-13-8) → 3-[(3-fluorobenzyl)oxy]aniline (865611-14-9)

Guidance literature:

With tin(II)chloride dihydrate; In ethanol; Reflux;

Reference yield:

C15H14FNO2 (1371060-06-8) → 3-[(3-fluorobenzyl)oxy]aniline (865611-14-9)

Guidance literature:

With water; sodium hydroxide; In ethanol; Reflux;

DOI:10.1055/s-0032-1312601

Reference yield:

meta-nitrophenol (554-84-7) → 3-[(3-fluorobenzyl)oxy]aniline (865611-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; potassium carbonate / acetone / Reflux

2: tin(II)chloride dihydrate / ethanol / Reflux

With tin(II)chloride dihydrate; potassium carbonate; sodium iodide; In ethanol; acetone;

upstream raw materials:

meta-hydroxyacetanilide

C₁₅H₁₄FNO₂

1-fluoro-3-((3-nitrophenoxy)methyl)benzene

meta-nitrophenol

Downstream raw materials:

C₁₅H₁₂FN₃O₂

Refernces

• 1、 De Candia, Modesto,Fiorella, Filomena,Lopopolo, Gianfranco,Carotti, Andrea,Romano, Maria Rosaria,Lograno, Marcello Diego,Martel, Sophie,Carrupt, Pierre-Alain,Belviso, Benny D.,Caliandro, Rocco,Altomare, Cosimo. "Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity". . p. 8696 - 8711. Retrieved 2013/12/04.
• 2、 Veeraswamy,Kurumurthy,Santhosh Kumar,Sambasiva Rao,Thelakkat, Kavya,Kotamraju, Srigiridhar,Narsaiah. "Synthesis of novel 5-substituted isoxazole-3-carboxamide derivatives and cytotoxicity studies on lung cancer cell line". . p. 1369 - 1375. Retrieved 2012/11/13.