2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime

Base Information

• Chemical Name: 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime
• CAS No.: 1446135-23-4
• Molecular Formula: C₁₆H₁₅N₅O
• Molecular Weight: 293.328
• Mol file: 1446135-23-4.mol

Synonyms:2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime

Chemical Property of 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime

There total 4 articles about 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone (116991-75-4) → 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime (1446135-23-4)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 3h; Reflux;

DOI:10.1021/jo4006552

Reference yield:

Benzoylacetonitrile (614-16-4) → 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime (1446135-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide; zinc dibromide / water; isopropyl alcohol / 36 h / 140 °C / Sealed tube

2: triethylamine / tetrahydrofuran / 18 h / 40 °C

3: hydroxylamine hydrochloride; pyridine / ethanol / 3 h / Reflux

With pyridine; sodium azide; hydroxylamine hydrochloride; triethylamine; zinc dibromide; In tetrahydrofuran; ethanol; water; isopropyl alcohol;

DOI:10.1021/jo4006552

Reference yield:

benzoic acid ethyl ester (93-89-0,99341-95-4) → 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime (1446135-23-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium 2-methylbutan-2-olate / tetrahydrofuran / 20 °C

2: sodium azide; zinc dibromide / water; isopropyl alcohol / 36 h / 140 °C / Sealed tube

3: triethylamine / tetrahydrofuran / 18 h / 40 °C

4: hydroxylamine hydrochloride; pyridine / ethanol / 3 h / Reflux

With pyridine; sodium azide; hydroxylamine hydrochloride; potassium 2-methylbutan-2-olate; triethylamine; zinc dibromide; In tetrahydrofuran; ethanol; water; isopropyl alcohol;

DOI:10.1021/jo4006552

upstream raw materials:

2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone

Benzoylacetonitrile

benzoic acid ethyl ester

1-phenyl-2-(1H-tetrazol-5-yl)ethanone

Downstream raw materials:

2-(1-benzyl-1H-tetrazol-5-yl)-3-phenyl-2H-azirine