(2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate

Base Information

Chemical Name:(2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate
CAS No.:1256160-12-9
Molecular Formula:C₂₂H₁₆F₂O₈
Molecular Weight:446.361
Hs Code.:

Synonyms:(2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate

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Chemical Property of (2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate

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Technology Process of (2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate

There total 7 articles about (2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1394226-60-8
(2R,3R)-5,7-bis(benzyloxy)-2-[3',4',5'-tris(benzyloxy)phenyl]chroman-3-yl 3,4-difluorobenzoate

: 1256160-12-9
(2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 5h;
DOI:10.1080/00397911.2011.585269

Reference yield:

: 1608504-27-3
C₅₂H₈₆F₂O₈Si₅

: 1256160-12-9
(2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate

Guidance literature:: With hydrogen fluoride; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1016/j.bmcl.2014.03.088

Reference yield:

: 455-86-7
3,4-Difluorobenzoic acid

: 1256160-12-9
(2R,3R)-5,7-bis(hydroxyl)-2-[3',4',5'-tris(hydroxy)phenyl]chroman-3-yl 3,4-difluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / Reflux

2: dmap / dichloromethane / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 20 °C

With dmap; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate;
DOI:10.1080/00397911.2011.585269