Technology Process of 2-[(1-methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride
There total 7 articles about 2-[(1-methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 1h;
DOI:10.1021/jm5010336
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.75 h / 80 °C / Inert atmosphere
2.1: sodium hydrogencarbonate; hydroxylamine hydrochloride / ethanol / 5 h / 55 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h / 20 °C
3.2: 21 h / 20 - 90 °C
4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); hydroxylamine hydrochloride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5010336
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate; hydroxylamine hydrochloride / ethanol / 5 h / 55 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h / 20 °C
2.2: 21 h / 20 - 90 °C
3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5010336