(S)-3-Amino-1-benzylpiperidine

Base Information

• Chemical Name: (S)-3-Amino-1-benzylpiperidine
• CAS No.: 307532-02-1
• Molecular Formula: C₁₂H₁₈N₂*2ClH
• Molecular Weight: 263.21
• Hs Code.: 29333990
• Mol file: 307532-02-1.mol

Synonyms:3-Piperidinamine,1-(phenylmethyl)-, dihydrochloride, (3S)- (9CI);

Chemical Property of (S)-3-Amino-1-benzylpiperidine

Chemical Property:

• Vapor Pressure: 0.00363mmHg at 25°C
• Melting Point: 237 °C (dec.)(lit.)
• Refractive Index: 1.56
• Boiling Point: 281.2°C at 760 mmHg
• Flash Point: 113.9°C
• PSA: 29.26000
• Density: 1.037g/cm³
• LogP: 3.85190
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-(+)-BENZYL-3-AMINOPIPERIDINEDIHYDROCHLORIDE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36-45-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Amino-1-benzylpiperidine

There total 12 articles about (S)-3-Amino-1-benzylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1-benzylpiperidin-3-yl)carbamic acid tert-butyl ester (478828-62-5,216854-24-9) → 3-amino-1-benzylpiperidine dihydrochloride (307532-02-1,368429-78-1,876160-18-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield: 67.0%

3-(N-acetamino)-1-benzylpiperidine (60169-74-6) → 3-amino-1-benzylpiperidine dihydrochloride (307532-02-1,368429-78-1,876160-18-8)

Guidance literature:

With hydrogenchloride; In water; for 1h; Heating;

DOI:10.1021/jm00182a007

Reference yield:

tert-butyl (S)-(N-benzylpiperidin-3-yl)carbamate (216854-24-9) → C12H18N2*(x)ClH (307532-02-1,368429-78-1,876160-18-8)

Guidance literature:

With hydrogenchloride; methanol; In water; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol302005f

upstream raw materials:

3-(N-acetamino)-1-benzylpiperidine

pyridin-3-ylamine

N-(pyridin-3-yl)acetamide

N-(piperidin3-yl)acetamide