2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid

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Chemical Name:2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid
CAS No.:1440092-60-3
Molecular Formula:C₃₀H₁₉NO₄S₃
Molecular Weight:553.683
Hs Code.:

Synonyms:2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid

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Chemical Property of 2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid

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Technology Process of 2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid

There total 10 articles about 2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1440092-72-7
3-chloro-2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-benzo[b]thiophene-6-carboxylic acid methyl ester

: 108-98-5
thiophenol

: 1440092-60-3
2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃; for 72h; Inert atmosphere;

Reference yield:

: 33923-98-7
2-amino-9H-thioxanthen-9-one

: 1440092-60-3
2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / Heating

2.1: sodium hydride / tetrahydrofuran / 0.25 h / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / water / 12 h / Reflux

4.1: triethylamine; dmap / dichloromethane / 48 h / 5 - 20 °C / Inert atmosphere

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 72 h / 80 °C / Inert atmosphere

With dmap; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 117390-07-5
(E)-4-(methoxycarbonyl)cinnamic acid

: 1440092-60-3
2-[methyl-(9-oxo-9H-thioxanthen-2-yl)-carbamoyl]-3-phenylsulfanyl-benzo[b]thiophene-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; thionyl chloride / 144 h / Reflux

1.2: Inert atmosphere; Reflux

2.1: triethylamine; dmap / dichloromethane / 48 h / 5 - 20 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 72 h / 80 °C / Inert atmosphere

With pyridine; dmap; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;