cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine

Base Information

• Chemical Name: cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine
• CAS No.: 944419-29-8
• Molecular Formula: C₁₅H₂₃NO
• Molecular Weight: 233.354
• Mol file: 944419-29-8.mol

Synonyms:cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine

Chemical Property of cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine

There total 3 articles about cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-heptandione (13505-34-5) + 4-Ethoxyaniline (156-43-4) → cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine (944419-29-8) + cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine + C15H23NO

Guidance literature:

With 5A molecular sieve; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (R)-TRIP; In cyclohexane; at 50 ℃; Title compound not separated from byproducts.;

DOI:10.1021/ja072134j

Reference yield:

3-methylcyclohexen-2-one (1193-18-6) + 4-Ethoxyaniline (156-43-4) → cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine (944419-29-8) + cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine + C15H23NO

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (R)-TRIP; In cyclohexane; at 50 ℃; Title compound not separated from byproducts.;

DOI:10.1021/ja072134j

Reference yield:

2,6-heptandione (13505-34-5) + 4-Ethoxyaniline (156-43-4) → cis-N-(p-ethoxyphenyl)-3-methylcyclohexaneamine (944419-29-8)

Guidance literature:

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In cyclohexane; at 50 ℃; Reagent/catalyst; enantioselective reaction; Mechanism; Molecular sieve;

DOI:10.1002/anie.200804353

upstream raw materials:

2,6-heptandione

4-Ethoxyaniline

3-methylcyclohexen-2-one

Downstream raw materials:

(1R,3S)-1-amino-3-methylcyclohexane