(1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

Base Information

Chemical Name:(1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester
CAS No.:1149625-72-8
Molecular Formula:C₃₁H₃₈Cl₂N₂O₆
Molecular Weight:605.559
Hs Code.:

(1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

Synonyms:(1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

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Chemical Property of (1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

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Technology Process of (1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

There total 1 articles about (1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 877995-77-2
1-(4-bromophenoxy)-2-(2,6-dichloro-4-methylphenoxy)ethane

: 1149624-39-4
(1R,5S)-9-methyl-7-trifluoromethanesulfonyloxy-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

: 1149625-72-8
(1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

Guidance literature:: 1-(4-bromophenoxy)-2-(2,6-dichloro-4-methylphenoxy)ethane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

(1R,5S)-9-methyl-7-trifluoromethanesulfonyloxy-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; for 1h; Inert atmosphere; Reflux;
DOI:10.1021/jm900022f

Reference yield:

: 1149625-72-8
(1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

: C₂₅H₂₈Cl₂N₂O₄

Guidance literature:: (1R,5S)-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-9-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester; With carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate; In 1,2-dichloro-ethane; at 80 ℃; for 3h; Inert atmosphere;

With methanol; at 60 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm900022f