1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

Base Information

Chemical Name:1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one
CAS No.:1309831-19-3
Molecular Formula:C₂₅H₃₃F₂N₉O
Molecular Weight:513.594
Hs Code.:

1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

Synonyms:1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

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Chemical Property of 1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

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Technology Process of 1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

There total 15 articles about 1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40327-96-6
4-amino-1,2,2,6,6-pentamethylpiperidine

: 1309831-19-3
1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 20 °C

2: toluene-4-sulfonic acid / isopropyl alcohol / 72 h / 110 °C / Sealed vial

With toluene-4-sulfonic acid; In methanol; isopropyl alcohol;

Reference yield:

: 1309831-16-0
1-(5-amino-2-cyclopropyl-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one

: 2-chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

: 1309831-19-3
1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

Guidance literature:: 1-(5-amino-2-cyclopropyl-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one; 2-chloro-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride; With toluene-4-sulfonic acid; In isopropyl alcohol; at 110 ℃; for 72h; Sealed vial;

With sodium hydroxide; In ethyl acetate;

Reference yield:

: 1003-98-1
2-bromo-4-fluoroaniline

: 1309831-19-3
1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; sulfuric acid / 1.08 h / -20 - -15 °C

2: toluene / 2.5 h / 80 °C / Inert atmosphere

3: trimethylsilylazide / 80 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / -78 - 20 °C / Inert atmosphere

5: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere

6: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 80 °C

7: toluene-4-sulfonic acid / isopropyl alcohol / 72 h / 110 °C / Sealed vial

With hydrogenchloride; tin(II) chloride dihdyrate; trimethylsilylazide; sulfuric acid; nitric acid; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; palladium diacetate; tricyclohexylphosphine; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 5: Suzuki Coupling;