2-methoxy-4-<3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenyl>-3-pivaloylaminopyridine

Base Information

Chemical Name:2-methoxy-4-<3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenyl>-3-pivaloylaminopyridine
CAS No.:131653-59-3
Molecular Formula:C₂₄H₃₃N₃O₆
Molecular Weight:459.543
Hs Code.:

Synonyms:2-methoxy-4-<3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenyl>-3-pivaloylaminopyridine

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Chemical Property of 2-methoxy-4-<3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenyl>-3-pivaloylaminopyridine

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Technology Process of 2-methoxy-4-<3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenyl>-3-pivaloylaminopyridine

There total 2 articles about 2-methoxy-4-<3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenyl>-3-pivaloylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 131653-62-8
2,2-dimethyl-N-(4-iodo-2-methoxy-3-pyridyl)propanamide

: 131653-74-2
3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenylboronic acid

: 131653-59-3
2-methoxy-4-<3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenyl>-3-pivaloylaminopyridine

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 12h; Heating;

Reference yield:

: 125867-19-8
N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide

: 131653-59-3
2-methoxy-4-<3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenyl>-3-pivaloylaminopyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / 1.) tetramethylethylenediamine, n-butyllithium; 2.) iodine / 1.) THF/hexane, -78 deg C, 15 min; -25 deg C, 2 h; 2.) THF, -78 deg C, 15 min; -25 deg C, 2 h

2: 88 percent / aq. sodium carbonate, ethanol / tetrakistriphenylphosphine palladium ⁽⁰⁾ / toluene / Heating

With n-butyllithium; ethanol; N,N,N,N,-tetramethylethylenediamine; iodine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene;
DOI:10.1016/0022-328X(95)05979-Y