N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate)

Base Information

• Chemical Name: N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate)
• CAS No.: 1259402-72-6
• Molecular Formula: C₅₈H₇₂N₅O₂₂P
• Molecular Weight: 1222.2

Synonyms:N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate)

Chemical Property of N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate)

Chemical Property:

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Technology Process of N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate)

There total 8 articles about N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2'-O-levulinoyl-N6-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-{bis[3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl] phosphate} (1259402-71-5) → N6-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate) (1259402-72-6)

Guidance literature:

With pyridine; hydrazine hydrate; acetic acid; at 20 ℃; for 3.5h; Cooling with ice;

DOI:10.1002/cbdv.201100144

Reference yield:

3'-O-{[(2,2-dimethylpropanoyl)oxy]methyl}-2'-O-(4-oxopentanoyl)adenosine → N6-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate) (1259402-72-6)

Guidance literature:

Multi-step reaction with 7 steps

1: pyridine / 2.5 h / 20 °C

2: 37 °C

3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

4: triethylamine / dichloromethane / 2 h / Inert atmosphere

5: 1H-tetrazole / acetonitrile / 0.5 h

6: 2,6-dimethylpyridine; water; iodine / tetrahydrofuran / 20 °C

7: pyridine; hydrazine hydrate; acetic acid / 3.5 h / 20 °C / Cooling with ice

With pyridine; 2,6-dimethylpyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; water; iodine; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1002/cbdv.201100144

Reference yield:

C49H64N7O9P (1259402-68-0) → N6-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-(bis{3-[(acetyloxy)methyl]-2,2-bis(ethoxycarbonyl)propyl} phosphate) (1259402-72-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-tetrazole / acetonitrile / 0.5 h

2: 2,6-dimethylpyridine; water; iodine / tetrahydrofuran / 20 °C

3: pyridine; hydrazine hydrate; acetic acid / 3.5 h / 20 °C / Cooling with ice

With pyridine; 2,6-dimethylpyridine; 1H-tetrazole; water; iodine; hydrazine hydrate; acetic acid; In tetrahydrofuran; acetonitrile;

DOI:10.1002/cbdv.201100144

upstream raw materials:

C₄₉H₆₄N₇O₉P

C₆₃H₇₈N₅O₂₃P

2'-O-levulinoyl-N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine 5'-{bis[3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl] phosphate}

2'-O-levulinoyl-N₆-[(4-methoxyphenyl)(diphenyl)methyl]-3'-O-[(pivaloyloxy)methyl]adenosine

Downstream raw materials:

C₆₆H₉₁N₇O₂₂P₂

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