(1R,5R,7R,8S)-8-benzyloxy-5-benzyloxymethyl-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane

Base Information

• Chemical Name: (1R,5R,7R,8S)-8-benzyloxy-5-benzyloxymethyl-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane
• CAS No.: 1104192-41-7
• Molecular Formula: C₂₇H₃₀N₂O₅
• Molecular Weight: 462.546
• Mol file: 1104192-41-7.mol

Synonyms:(1R,5R,7R,8S)-8-benzyloxy-5-benzyloxymethyl-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane

Chemical Property of (1R,5R,7R,8S)-8-benzyloxy-5-benzyloxymethyl-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (1R,5R,7R,8S)-8-benzyloxy-5-benzyloxymethyl-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane

There total 2 articles about (1R,5R,7R,8S)-8-benzyloxy-5-benzyloxymethyl-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

C29H32N2O6S2 (1254203-74-1) → (1R,5R,7R,8S)-8-benzyloxy-5-benzyloxymethyl-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane (1104192-41-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 1.5h; Reflux;

DOI:10.1021/jo101207d

Reference yield: 72.0%

(1R,4R,5S,7R,8S)-8-benzyloxy-5-benzyloxymethyl-4-(O-phenoxythiocarbonyl)-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane (1104192-40-6) → (1R,5R,7R,8S)-8-benzyloxy-5-benzyloxymethyl-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane (1104192-41-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 1h; Reflux; Inert atmosphere;

DOI:10.1039/b813870b

upstream raw materials:

(1R,4R,5S,7R,8S)-8-benzyloxy-5-benzyloxymethyl-4-(O-phenoxythiocarbonyl)-7-(thymin-1-yl)-6-oxa-bicyclo[3.2.1]octane

C₂₉H₃₂N₂O₆S₂