7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

Base Information

Chemical Name:7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole
CAS No.:744145-76-4
Molecular Formula:C₂₆H₂₁F₃N₂O
Molecular Weight:434.461
Hs Code.:

Synonyms:7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

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Chemical Property of 7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

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Technology Process of 7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

There total 4 articles about 7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 58039-25-1
7-fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo<3,4-b>indole

: 744145-76-4
7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

Guidance literature:: With sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 150 ℃; for 2h; Yield given;
DOI:10.1021/jm00180a030

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 744145-76-4
7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium acetate, 2.) 85percent H₃PO₄ / 1.) water, 20 min, 2.) RT, 1 h

2: 60 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidinone / 4 h / Heating

3: KOH / ethanol; H₂O / 18 h / Heating

4: Na₂CO₃, KI / dimethylformamide / 2 h / 150 °C

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; potassium hydroxide; phosphoric acid; sodium acetate; sodium carbonate; potassium iodide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a030

Reference yield:

: 58039-18-2
7-fluoro-2-carbethoxy-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

: 744145-76-4
7-fluoro-4-(p-fluorophenyl)-2-[3-(p-fluorobenzoyl)propyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidinone / 4 h / Heating

2: KOH / ethanol; H₂O / 18 h / Heating

3: Na₂CO₃, KI / dimethylformamide / 2 h / 150 °C

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; potassium hydroxide; sodium carbonate; potassium iodide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a030