(S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol

Base Information

Chemical Name:(S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol
CAS No.:1332850-66-4
Molecular Formula:C₁₄H₂₀FNO₃
Molecular Weight:269.316
Hs Code.:

Synonyms:(S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol

Suppliers and Price of (S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol

There total 6 articles about (S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1332850-65-3
(3S,4R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine

: 1332850-66-4
(S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol

Guidance literature:: (3S,4R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine; With boron trichloride; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;

With methanol; In dichloromethane; Inert atmosphere;
DOI:10.1016/j.jfluchem.2011.05.031

Reference yield:

: 1332850-64-2
(2S,3R,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3-fluoropentane-1,5-diol

: 1332850-66-4
(S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2.1: 18 h / 80 °C

3.1: boron trichloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.2: Inert atmosphere

With dmap; boron trichloride; triethylamine; In dichloromethane;
DOI:10.1016/j.jfluchem.2011.05.031

Reference yield:

: 1332850-62-0
(4S,5R,6R,E)-6-((S)-1,2-bis(benzyloxy)ethyl)-5-fluoroocta-2,7-dien-4-ol

: 1332850-66-4
(S)-1-((3R,4R,5S)-1-benzyl-4-fluoro-5-hydroxypiperidin-3-yl)ethane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: ozone / methanol; dichloromethane / -78 °C

2.2: 3 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

4.1: 18 h / 80 °C

5.1: boron trichloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

5.2: Inert atmosphere

With dmap; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1016/j.jfluchem.2011.05.031