(S)-3-Amino-1,2-propanediol

Base Information

• Chemical Name: (S)-3-Amino-1,2-propanediol
• CAS No.: 61278-21-5
• Molecular Formula: C3H9NO2
• Molecular Weight: 91.11
• Hs Code.: 29221990
• Mol file: 61278-21-5.mol

Synonyms:1,2-Propanediol,3-amino-, (S)-;(-)-3-Amino-1,2-propanediol;(2S)-3-Amino-2-hydroxypropanol;(2S)-3-Aminopropane-1,2-diol;(S)-(-)-3-Amino-1,2-propanediol;(S)-2,3-Dihydroxypropylamine;(S)-3-Amino-1,2-propanediol;S-Amino-1,2-propanediol;

Chemical Property of (S)-3-Amino-1,2-propanediol

Chemical Property:

• Vapor Pressure: 0.00116mmHg at 25°C
• Melting Point: 54-56oC
• Refractive Index: n20/D 1.483(lit.)
• Boiling Point: 266.7 °C at 760 mmHg
• PKA: 12.11±0.35(Predicted)
• Flash Point: 115.1 °C
• PSA: 66.48000
• Density: 1.181 g/cm³
• LogP: -1.00140
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Moisture Sensitive
• Water Solubility.: Soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

(S)-3-Amino-1,2-propanediol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-(-)-3-Amino-1,2-propanediol is used as a chiral selector ligand, used subsequently for a nucleophilic substitution with the dimethoxytrityl (DMT)-protected

Technology Process of (S)-3-Amino-1,2-propanediol

There total 11 articles about (S)-3-Amino-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methanamine (82954-65-2,96894-67-6) → (S)-3-Amino-1,2-propanediol (61278-21-5,98923-21-8)

Guidance literature:

With acid;

Reference yield:

(R)-oxiranemethanol (57044-25-4) → (S)-3-Amino-1,2-propanediol (61278-21-5,98923-21-8)

Guidance literature:

With ammonia; In isopropyl alcohol; for 48h; Ambient temperature;

DOI:10.1021/jm00048a007

Reference yield:

3-Amino-1,2-propanediol (616-30-8,13552-31-3,98923-21-8) → (S)-3-Amino-1,2-propanediol (61278-21-5,98923-21-8) + (R)-3-amino-1,2-propanediol (66211-46-9,98923-21-8)

Guidance literature:

With chiral stationary phase including isopropyl-functionalized CF₆; In methanol; acetic acid; triethylamine; acetonitrile; at 20 ℃; Purification / work up;

upstream raw materials:

(R)-3-tosyloxy-1,2-propanediol

(S)-3-Benzyloxy-2-hydroxy-propionitrile

[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methanamine

(R)-oxiranemethanol

Downstream raw materials:

(S)-1-<(tert-butoxycarbonyl)amino>-2,3-dihydroxypropane

(S)-5-(hydroxymethyl)-1,3-oxazolidin-2-one

(S)-3-[N-(benzyloxycarbonyl)amino]-1,2-propanediol

N-(2,3-dihydroxy-propyl)-4-phenylazo-benzamide