4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Base Information

Chemical Name:4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine
CAS No.:1013403-80-9
Molecular Formula:C₂₂H₁₉F₃N₆O
Molecular Weight:440.428
Hs Code.:

Synonyms:4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

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Chemical Property of 4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

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Technology Process of 4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

There total 5 articles about 4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1012317-17-7
1-[4-chloro-6-(morpholin-4-yl)pyrimidin-2-yl]-2-(difluoromethyl)-1H-benzimidazole

: 819058-34-9
2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1013403-80-9
4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 0.25h; microwave irradiation;

Reference yield:

: 52127-83-0
4-(2,6-dichloropyrimidin-4-yl)morpholine

: 1013403-80-9
4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 100 °C / microwave irradiation

With sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1013403-80-9
4-(4-amino-3-fluorophenyl)-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / palladium diacetate / N,N-dimethyl-formamide / 18 h / 80 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 100 °C / microwave irradiation

With potassium acetate; sodium carbonate; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;