{methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester

Base Information

Chemical Name:{methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester
CAS No.:868262-39-9
Molecular Formula:C₂₄H₂₈N₂O₃S
Molecular Weight:424.564
Hs Code.:

Synonyms:{methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester

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Chemical Property of {methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester

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Technology Process of {methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester

There total 2 articles about {methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.8%

: 3034-53-5,215777-74-5
2-bromo-1,3-thiazole

: 868265-67-2
(methyl-(2-[3-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-biphenyl-4-yloxy]ethyl)-amino)-acetic acid tert-butyl ester

: 868262-39-9
{methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In 1,4-dioxane; at 110 ℃; for 3h;

Reference yield:

: 868265-66-1
{[2-(3-iodobiphenyl-4-yloxy)ethyl]-methylamino}-acetic acid tert-butyl ester

: 389630-95-9
(thiazol-2-yl)boronic acid

: 868262-39-9
{methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: With potassium fluoride; tricyclohexylphosphine; palladium diacetate; In tetrahydrofuran; Heating;
DOI:10.1016/j.bmcl.2007.06.074

Reference yield: 93.0%

: 868262-39-9
{methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester

: {methyl-[2-(3-thiazol-2-yl-biphenyl-4-yloxy)ethyl]-amino}-acetic acid hydrochloride

Guidance literature:: {methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester; With sodium hydroxide; water; In 1,4-dioxane; at 115 ℃; for 3h;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; water; pH=1;