(-)-(R)-3-(7-oxooxepan-2-yl)propionitrile

Base Information

Chemical Name:(-)-(R)-3-(7-oxooxepan-2-yl)propionitrile
CAS No.:1046202-47-4
Molecular Formula:C₉H₁₃NO₂
Molecular Weight:167.208
Hs Code.:

Synonyms:(-)-(R)-3-(7-oxooxepan-2-yl)propionitrile

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Chemical Property of (-)-(R)-3-(7-oxooxepan-2-yl)propionitrile

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Technology Process of (-)-(R)-3-(7-oxooxepan-2-yl)propionitrile

There total 4 articles about (-)-(R)-3-(7-oxooxepan-2-yl)propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 4594-78-9
cyclohexanone-2-propionitrile

: 1046202-47-4
(-)-(R)-3-(7-oxooxepan-2-yl)propionitrile

: 4594-78-9,58769-43-0,58800-16-1,24773-62-4
(+)-(S)-3-(2-oxocyclohexyl)propionitrile

Guidance literature:: With cyclohexanone MO-type from Arthrobacter sp. BP₂; oxygen; In 1,4-dioxane; for 10.5h; Reagent/catalyst; Time; regioselective reaction; Enzymatic reaction;
DOI:10.1016/j.tet.2015.12.047

Reference yield:

: 4594-78-9
cyclohexanone-2-propionitrile

: 1046202-47-4
(-)-(R)-3-(7-oxooxepan-2-yl)propionitrile

: 4594-78-9,58769-43-0,58800-16-1,24773-62-4
(+)-(S)-3-(2-oxocyclohexyl)propionitrile

: 3-(2-oxocyclohexyl)propionitrile

Guidance literature:: With Gln₉₃Asn/Pro₉₄Asp mutant phenylacetone monooxygenase; Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase; nicotinamide adenine dinucleotide; isopropyl alcohol; In acetonitrile; at 30 ℃; pH=8; optical yield given as %ee; enantioselective reaction; aq. buffer;
DOI:10.1073/pnas.0911656107

Reference yield:

: 1125-99-1
1-(1-Cyclohexen-1-yl)pyrrolidine

: 1046202-47-4
(-)-(R)-3-(7-oxooxepan-2-yl)propionitrile

: 4594-78-9,58769-43-0,58800-16-1,24773-62-4
(+)-(S)-3-(2-oxocyclohexyl)propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-dioxane / Inert atmosphere; Reflux

1.2: Reflux

2.1: oxygen; cyclohexanone MO-type from Arthrobacter sp. BP₂ / 1,4-dioxane / 10.5 h / Enzymatic reaction

With cyclohexanone MO-type from Arthrobacter sp. BP₂; oxygen; In 1,4-dioxane;
DOI:10.1016/j.tet.2015.12.047