(R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1442445-29-5
Molecular Formula:C₂₅H₂₇ClFN₃O₂
Molecular Weight:455.96
Hs Code.:

Synonyms:(R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of (R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of (R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 7 articles about (R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1442445-28-4
(R)-6-bromo-1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazole

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1442445-29-5
(R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1442445-18-2
(S)-N-(1-(4-chloro-2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1442445-29-5
(R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: L-Selectride / tetrahydrofuran / 18 h / -45 - 20 °C

2: hydrogenchloride / methanol; 1,4-dioxane / 18 h / 0 - 20 °C

3: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

4: hydrogenchloride; iron; acetic acid / ethanol; water / 1 h / 90 °C

5: 1 h / 100 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 2 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; L-Selectride; iron; potassium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; toluene;

Reference yield:

: 856562-68-0
(S)-N-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide

: 1442445-29-5
(R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 18 h / 0 - 20 °C

2: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

3: hydrogenchloride; iron; acetic acid / ethanol; water / 1 h / 90 °C

4: 1 h / 100 °C

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 2 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; acetic acid; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; toluene;