N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane

Base Information

• Chemical Name: N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane
• CAS No.: 1310361-02-4
• Molecular Formula: C₃₂H₄₂N₂O₄Si
• Molecular Weight: 546.782
• Mol file: 1310361-02-4.mol

Synonyms:N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane

Chemical Property of N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane

There total 3 articles about N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl N-(6-aminohexyl)carbamate (51857-17-1) + 4-nitrophenyl 2-(triphenylsilyl)ethyl carbonate (1310360-86-1) → N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane (1310361-02-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.3390/molecules16064695

Reference yield:

vinyltriphenylsilane (18666-68-7) → N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane (1310361-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

1.2: 3 h / 45 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With pyridine; triethylamine; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules16064695

Reference yield:

1,1,1-triphenyl-1-silapropan-3-ol (18666-87-0) → N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(tert-butoxycarbonyl)-1,6-diaminohexane (1310361-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With pyridine; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules16064695

upstream raw materials:

tert-butyl N-(6-aminohexyl)carbamate

4-nitrophenyl 2-(triphenylsilyl)ethyl carbonate

1,1,1-triphenyl-1-silapropan-3-ol

vinyltriphenylsilane

Downstream raw materials:

N-(2-(triphenylsilyl)ethoxy)carbonyl-N'-(N-tert-butoxycarbonyl-L-alanyl)-1,6-diaminohexane