3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester

Base Information

• Chemical Name: 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester
• CAS No.: 133167-05-2
• Molecular Formula: C₁₆H₁₆Cl₂N₂O₄
• Molecular Weight: 371.22

Synonyms:3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester

Chemical Property of 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester

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Technology Process of 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester

There total 2 articles about 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.6%

1-<(3,4-dichlorophenyl)methyl>-5,6-dimethyl-2,4(1H,3H)-pyrimidinedione (133167-04-1) + bromoacetic acid methyl ester (96-32-2) → 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester (133167-05-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

DOI:10.1021/jm00108a038

Reference yield:

5,6-dimethyl-2H,4H-1,3-oxazine-2,4-dione (61736-31-0) → 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester (133167-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 25.1 percent / ethanol / 1.5 h / 110 °C

2: 76.6 percent / K₂CO₃ / dimethylformamide / 4 h / 60 °C

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00108a038

Reference yield: 77.0%

3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester (133167-05-2) → 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid (133166-79-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; for 1h;

DOI:10.1021/jm00108a038

upstream raw materials:

1-<(3,4-dichlorophenyl)methyl>-5,6-dimethyl-2,4(1H,3H)-pyrimidinedione

bromoacetic acid methyl ester

5,6-dimethyl-2H,4H-1,3-oxazine-2,4-dione

Downstream raw materials:

3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid

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