methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate

Base Information

Chemical Name:methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate
CAS No.:126191-14-8
Molecular Formula:C₁₉H₁₈F₃NO₄
Molecular Weight:381.351
Hs Code.:

Synonyms:methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate

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Chemical Property of methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate

Chemical Property:

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Technology Process of methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate

There total 7 articles about methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 19883-41-1,13226-98-7
D-phenylglycine methyl ester hydrochloride

: 126191-14-8
methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ja060529h

Reference yield:

: 98-80-6
phenylboronic acid

: 126191-14-8
methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 1,2-bis(diphenylphosphino)benzene / Rh(acac)(coe)2 / dioxane / 16 h / 70 °C

2: HCl / dioxane; methanol / 20 °C

3: Hunig's base / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; o-phenylenebis(diphenylphosphine); N-ethyl-N,N-diisopropylamine; {rhodium(acetylacetonate)(cis-cyclooctene)2}; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ja060529h

Reference yield:

: (R)-(2-Methyl-propane-2-sulfinylamino)-phenyl-acetic acid methyl ester

: 126191-14-8
methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane; methanol / 20 °C

2: Hunig's base / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ja060529h