(E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane

Base Information

Chemical Name:(E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane
CAS No.:1361412-40-9
Molecular Formula:C₂₉H₄₀O₄Si
Molecular Weight:480.72
Hs Code.:

Synonyms:(E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane

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Chemical Property of (E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane

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Technology Process of (E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane

There total 4 articles about (E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1361412-19-2
2-(3,3-bis(benzyloxymethyl)hex-5-ynyl)-1,3-dioxolane

: 18107-18-1
diazomethyl-trimethyl-silane

: 1361412-40-9
(E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane

Guidance literature:: With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In diethyl ether; hexane; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201107344

Reference yield:

: 96964-51-1
dimethyl 2-(2-(1,3-dioxolan-2-yl)ethyl)malonate

: 1361412-40-9
(E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.2: 12 h / 20 °C / Inert atmosphere

4.1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / diethyl ether; hexane / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); sodium hydride; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201107344

Reference yield:

: 1361412-16-9
dimethyl 2-(2-(1,3-dioxolan-2-yl)ethyl)-2-(prop-2-ynyl)malonate

: 1361412-40-9
(E)-(2-(8,8-bis(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-6-yl)vinyl)trimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / diethyl ether; hexane / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); sodium hydride; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201107344