(2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol

Base Information

Chemical Name:(2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol
CAS No.:119139-45-6
Molecular Formula:C₄₁H₅₁NO₅SSi
Molecular Weight:698.011
Hs Code.:

Synonyms:(2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol

Suppliers and Price of (2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol

There total 18 articles about (2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 119139-44-5
(2S)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-6,7-dimethyl-3-methylene-6-octen-2-ol

: 119139-45-6
(2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol

Guidance literature:: With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; In dichloromethane; at 0 ℃; for 2.5h;
DOI:10.1246/cl.1988.909

Reference yield:

: 5072-70-8
1-bromo-2,3-dimethyl-2-butene

: 119139-45-6
(2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol

Guidance literature:: Multi-step reaction with 6 steps

2: 87 percent / CH₂Cl₂ / 52 h / Ambient temperature

4: (L)-(+)-DET, Ti(OiPr)4, TBHP / CH₂Cl₂ / 1.5 h / -20 °C

6: 96 percent / TBHP / VO(acac)2 / CH₂Cl₂ / 2.5 h / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; bis(acetylacetonate)oxovanadium; In dichloromethane;
DOI:10.1246/cl.1988.909

Reference yield:

: 119139-40-1
5-(tert-butyldiphenylsilyl)oxymethyl-1-(p-toluenesulfonyl)-2-indolinole

: 119139-45-6
(2S,3R)-1-<5-(tert-butyldiphenylsilyl)oxymethyl-2-(p-toluenesulfonyl)aminophenyl>-3-(3,4-dimethyl-3-pentenyl)-3,4-epoxy-2-butanol

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / CH₂Cl₂ / 52 h / Ambient temperature

2: 92 percent / DIBALH / toluene / 0.5 h / -15 °C

3: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

4: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

5: aq. citric acid*H₂O / diethyl ether; methanol / 0.83 h / Ambient temperature

6: L-(+)-diethyl tartrate, Ti(O-Pr)4, tert-butyl hydroperoxide / CH₂Cl₂ / 1.5 h / -20 °C

7: 95 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

8: 87 percent / Zn, NaI / dimethylformamide / 0.25 h / 100 °C

9: 98 percent / DIBALH / toluene; hexane / 0.5 h / -15 °C

10: 96 percent / vanadyl acetylacetonate, tert-butyl hydroperoxide / CH₂Cl₂ / 2.5 h / 0 °C

With tert.-butylhydroperoxide; titanium tetra-n-propoxide; diethyl (2R,3R)-tartrate; vanadyl acetylacetonate; diisobutylaluminium hydride; triethylamine; citric acid; sodium iodide; zinc; In methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(96)00608-4