3-chlorocinnamyl bromide

Base Information

• Chemical Name: 3-chlorocinnamyl bromide
• CAS No.: 52925-45-8
• Molecular Formula: C₉H₈BrCl
• Molecular Weight: 231.52
• Mol file: 52925-45-8.mol

Synonyms:3-chlorocinnamyl bromide

Chemical Property of 3-chlorocinnamyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chlorocinnamyl bromide

There total 4 articles about 3-chlorocinnamyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(3-chlorophenyl)propenal (770-23-0,56578-37-1) → 3-chlorocinnamyl bromide (52925-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

2: phosphorus tribromide / diethyl ether / 0.17 h / 0 - 20 °C

With sodium tetrahydroborate; phosphorus tribromide; In methanol; diethyl ether;

DOI:10.1021/acs.jmedchem.7b00949

Reference yield:

m-Chlorobenzaldehyde (587-04-2) → 3-chlorocinnamyl bromide (52925-45-8)

Guidance literature:

Multi-step reaction with 2 steps

2: phosphorus tribromide

With phosphorus tribromide;

DOI:10.1021/acs.orglett.6b01514

Reference yield:

ethyl (E)-3-(3-chlorophenyl)prop-2-enoate (2373-88-8,118315-76-7,62174-98-5) → 3-chlorocinnamyl bromide (52925-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride

2: phosphorus tribromide

With phosphorus tribromide; diisobutylaluminium hydride;

DOI:10.1021/acs.orglett.6b01514

upstream raw materials:

ethyl (E)-3-(3-chlorophenyl)prop-2-enoate

m-Chlorobenzaldehyde

(E)-3-(3-chlorophenyl)propenal

3-iodochlorobenzene

Downstream raw materials:

1-(3-chloroprophenyl)propene-3-d1

(E)-(3-(3-chlorophenyl)allyl)(trifluoromethyl)sulfane

Refernces

• 1、 Li, Baoli,Ni, Shuaishuai,Mao, Fei,Chen, Feifei,Liu, Yifu,Wei, Hanwen,Chen, Wenhua,Zhu, Jin,Lan, Lefu,Li, Jian. "Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity". . p. 224 - 250. Retrieved 2018/02/10.
• 2、 Ni, Shuaishuai,Wei, Hanwen,Li, Baoli,Chen, Feifei,Liu, Yifu,Chen, Wenhua,Xu, Yixiang,Qiu, Xiaoxia,Li, Xiaokang,Lu, Yanli,Liu, Wenwen,Hu, Linhao,Lin, Dazheng,Wang, Manjiong,Zheng, Xinyu,Mao, Fei,Zhu, Jin,Lan, Lefu,Li, Jian. "Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo". . p. 8145 - 8159. Retrieved 2017/10/18.