7-octahydro-2H-pyrido<1,2-a>pyrazine

Base Information

• Chemical Name: 7-octahydro-2H-pyrido<1,2-a>pyrazine
• CAS No.: 146367-40-0
• Molecular Formula: C₂₁H₂₂F₂N₂
• Molecular Weight: 340.416

Synonyms:7-octahydro-2H-pyrido<1,2-a>pyrazine

Chemical Property of 7-octahydro-2H-pyrido<1,2-a>pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-octahydro-2H-pyrido<1,2-a>pyrazine

There total 10 articles about 7-octahydro-2H-pyrido<1,2-a>pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(ethoxycarbonyl)-7-octahydro-2H-pyrido<1,2-a>pyrazine (146367-38-6) → 7-octahydro-2H-pyrido<1,2-a>pyrazine (146367-40-0)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; for 1h; Heating;

DOI:10.1021/jo00055a023

Reference yield:

diethyl 2-acetylglutarate (1501-06-0) → 7-octahydro-2H-pyrido<1,2-a>pyrazine (146367-40-0)

Guidance literature:

Multi-step reaction with 9 steps

1: Br₂ / diethyl ether / 20 h / Ambient temperature

3: 2N HCl / methanol / 1 h / Heating

4: 1) NaCNBH₃, 2N HCl / 1) MeOH, 2.5 h reflux, 2) CH₂Cl₂, 3 h, RT

5: 1) LDA / 1) THF, hexane, -15 deg C, 20 min, 2) THF, -15 deg C, 15 min

6: 96 percent / 48percent HBr / CH₂Cl₂ / 0.67 h

7: 90 percent / LiAlH₄ / tetrahydrofuran / 0.5 h

8: 94 percent / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) RT, 1 h

9: 93 percent / KOH / propan-2-ol / 1 h / Heating

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; hydrogen bromide; bromine; sodium cyanoborohydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; isopropyl alcohol;

DOI:10.1021/jo00055a023

Reference yield:

diethyl 2-(bromoacetyl)glutarate (41845-25-4) → 7-octahydro-2H-pyrido<1,2-a>pyrazine (146367-40-0)

Guidance literature:

Multi-step reaction with 8 steps

2: 2N HCl / methanol / 1 h / Heating

3: 1) NaCNBH₃, 2N HCl / 1) MeOH, 2.5 h reflux, 2) CH₂Cl₂, 3 h, RT

4: 1) LDA / 1) THF, hexane, -15 deg C, 20 min, 2) THF, -15 deg C, 15 min

5: 96 percent / 48percent HBr / CH₂Cl₂ / 0.67 h

6: 90 percent / LiAlH₄ / tetrahydrofuran / 0.5 h

7: 94 percent / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) RT, 1 h

8: 93 percent / KOH / propan-2-ol / 1 h / Heating

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; hydrogen bromide; sodium cyanoborohydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

DOI:10.1021/jo00055a023

upstream raw materials:

2-(ethoxycarbonyl)-7-octahydro-2H-pyrido<1,2-a>pyrazine

diethyl 2-acetylglutarate

diethyl 2-(bromoacetyl)glutarate

4,4'-Difluorobenzophenone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 146367-40-0 7-octahydro-2H-pyrido<1,2-a>pyrazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send