(R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride

Base Information

Chemical Name:(R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride
CAS No.:1196091-23-2
Molecular Formula:C₂₈H₃₅FN₃O₃*Cl
Molecular Weight:516.056
Hs Code.:

Synonyms:(R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride

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Chemical Property of (R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride

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Technology Process of (R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride

There total 11 articles about (R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1196093-29-4
2-Chloro-N-(5-fluoro-pyridin-3-yl)-acetamide

: 1026791-31-0
1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

: 1196091-23-2
(R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride

Guidance literature:: In acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 502-42-1
cycloheptanone

: 1196091-23-2
(R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: iodine; magnesium / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux

1.2: 0.17 h

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 60 °C

2.2: 60 °C / Reflux

3.1: potassium; sodium / diethyl ether / 20 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

3.3: pH 7

4.1: trimethylsilyldiazomethane / toluene / 0.75 h / Inert atmosphere

5.1: toluene / 0.5 h / Reflux

5.2: Inert atmosphere; Reflux

6.1: acetonitrile / 24 h / 20 °C

With iodine; sodium; potassium; sodium hydride; magnesium; trimethylsilyldiazomethane; In tetrahydrofuran; diethyl ether; toluene; acetonitrile; mineral oil;

Reference yield:

: 6004-52-0
cycloheptyl(phenyl)methanone

: 1196091-23-2
(R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / 1 h / 0 °C

1.2: Reflux

2.1: water / silver nitrate / 1,4-dioxane / 4.5 h / 75 °C

3.1: trimethylsilyldiazomethane / toluene / 0.75 h / Inert atmosphere

4.1: toluene / 0.5 h / Reflux

4.2: Inert atmosphere; Reflux

5.1: acetonitrile / 24 h / 20 °C

With sulfuryl dichloride; water; trimethylsilyldiazomethane; silver nitrate; In 1,4-dioxane; toluene; acetonitrile;