1-methyl-4-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine

Base Information

• Chemical Name: 1-methyl-4-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine
• CAS No.: 1410789-55-7
• Molecular Formula: C₂₉H₃₆N₂O
• Molecular Weight: 428.618

Synonyms:1-methyl-4-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine

Chemical Property of 1-methyl-4-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-4-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine

There total 4 articles about 1-methyl-4-{4-[α-(1-tricyclo[3.3.1.1^3,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[α-(1-tricyclo[3.3.1.13,7]decyl)phenylmethyl]benzene carboxylic acid → 1-methyl-4-{4-[α-(1-tricyclo[3.3.1.13,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine (1410789-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Reflux

2: tetrahydrofuran / 3 h / 0 °C / Reflux

With thionyl chloride; In tetrahydrofuran;

DOI:10.1021/jm3013008

Reference yield:

1.4-dibromobenzene (106-37-6) → 1-methyl-4-{4-[α-(1-tricyclo[3.3.1.13,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine (1410789-55-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium / diethyl ether / Inert atmosphere; Reflux

1.2: 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

2.3: 0 °C

3.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 3 h / Inert atmosphere; Reflux

3.2: 3 h / 20 °C / Inert atmosphere

3.3: 0 °C / Inert atmosphere

4.1: thionyl chloride / 1 h / Reflux

5.1: tetrahydrofuran / 3 h / 0 °C / Reflux

With thionyl chloride; iodine; magnesium; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; ethylene dibromide;

DOI:10.1021/jm3013008

Reference yield:

α-(4-bromophenyl)-α-phenyl-1-tricyclo[3.3.1.13,7]-decanemethanol (1410789-53-5) → 1-methyl-4-{4-[α-(1-tricyclo[3.3.1.13,7]decyl)phenylmethyl]phenylcarbonyl}pirerazine (1410789-55-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

1.3: 0 °C

2.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 3 h / Inert atmosphere; Reflux

2.2: 3 h / 20 °C / Inert atmosphere

2.3: 0 °C / Inert atmosphere

3.1: thionyl chloride / 1 h / Reflux

4.1: tetrahydrofuran / 3 h / 0 °C / Reflux

With thionyl chloride; iodine; magnesium; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethylene dibromide;

DOI:10.1021/jm3013008

upstream raw materials:

1-methyl-piperazine

1.4-dibromobenzene

α-(4-bromophenyl)-α-phenyl-1-tricyclo[3.3.1.1^3,7]-decanemethanol

Downstream raw materials:

C₂₉H₃₈N₂

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