ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate

Base Information

• Chemical Name: ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate
• CAS No.: 159531-01-8
• Molecular Formula: C₁₈H₃₄O₂Si
• Molecular Weight: 310.552
• Mol file: 159531-01-8.mol

Synonyms:ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate

Chemical Property of ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate

There total 1 articles about ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-trimethylsilyl-2-diethylphosphonopropionic acid ethyl ester (110481-61-3) + 4-tercbutyl-cyclohexanone (98-53-3) → ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate (159531-01-8)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; at 70 ℃; Yield given;

DOI:10.1016/0040-4039(94)85034-8

Reference yield:

ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate (159531-01-8) → 2-(4-t-butylcyclohexylidene)-3-trimethylsilyl-1-propanol (306326-65-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;

DOI:10.1016/0040-4039(94)85034-8

Reference yield:

ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate (159531-01-8) → 4-(4-t-butylcyclohexylidene)-5-(trimethylsilyl)pent-1-en-3-one (159531-10-9)

Guidance literature:

Multi-step reaction with 4 steps

1: LiAlH₄ / diethyl ether / 0 °C

2: MnO₂ / CH₂Cl₂ / 20 °C

3: tetrahydrofuran / 20 °C

4: MnO₂ / CH₂Cl₂ / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Reduction / 2: Oxidation / 3: Grignard reaction / 4: Oxidation;

DOI:10.1016/S0040-4020(00)00589-5

upstream raw materials:

3-trimethylsilyl-2-diethylphosphonopropionic acid ethyl ester

4-tercbutyl-cyclohexanone

Downstream raw materials:

2-(4-t-butylcyclohexylidene)-3-trimethylsilyl-1-propanol

2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanal

4-(4-t-butylcyclohexylidene)-5-(trimethylsilyl)pent-1-en-3-one

4-(4-t-butylcyclohexylidene)-5-(trimethylsilyl)pent-1-en-3-ol