Technology Process of N-(N-(3-(1H-indol-2-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride
There total 5 articles about N-(N-(3-(1H-indol-2-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(3-(1H-indol-2-yl)phenylcarbamothioyl)-3,4,5-trimethoxybenzamide;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane;
In
acetonitrile;
at 20 ℃;
for 5h;
Inert atmosphere;
Cooling with ice;
With
hydrogenchloride;
In
diethyl ether; ethyl acetate;
Inert atmosphere;
DOI:10.1021/jm2013369
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / Inert atmosphere; Microwave irradiation
2.1: acetone / 1 h / Inert atmosphere; Reflux
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice
3.2: Inert atmosphere
With
palladium 10% on activated carbon; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane;
In
isopropyl alcohol; acetone; acetonitrile;
DOI:10.1021/jm2013369
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetone / 0.33 h / Inert atmosphere; Reflux
2.1: acetone / 1 h / Inert atmosphere; Reflux
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice
3.2: Inert atmosphere
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane;
In
acetone; acetonitrile;
DOI:10.1021/jm2013369
