N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide

Base Information

Chemical Name:N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide
CAS No.:1426224-69-2
Molecular Formula:C₂₄H₂₄BrFN₄O₂S
Molecular Weight:531.449
Hs Code.:

Synonyms:N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide

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Chemical Property of N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide

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Technology Process of N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide

There total 4 articles about N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 2131-59-1
3-bromophenyl isothiocyanate

: 1426224-76-1
C₁₇H₂₀FN₃O₂*C₂HF₃O₂

: 1426224-69-2
N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2012.12.029

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1426224-69-2
N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0 - 20 °C / pH 8

2.1: 0.75 h

3.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 8 h / 0 - 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.12.029

Reference yield:

: 84163-13-3
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

: 1426224-69-2
N-(3-bromophenyl)-2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)pyrrolidine-1-carbothioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0 - 20 °C / pH 8

2.1: 0.75 h

3.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 8 h / 0 - 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.12.029