C₆₀H₆₅Br₅N₄O₁₂Si

Base Information

• Chemical Name: C₆₀H₆₅Br₅N₄O₁₂Si
• CAS No.: 845784-24-9
• Molecular Formula: C₆₀H₆₅Br₅N₄O₁₂Si
• Molecular Weight: 1461.8
• Mol file: 845784-24-9.mol

Synonyms:C₆₀H₆₅Br₅N₄O₁₂Si

Chemical Property of C₆₀H₆₅Br₅N₄O₁₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₀H₆₅Br₅N₄O₁₂Si

There total 24 articles about C₆₀H₆₅Br₅N₄O₁₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C60H66Br4N4O12Si (845784-22-7) → C60H65Br5N4O12Si (845784-24-9)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 0 ℃; for 2h;

DOI:10.1002/chem.200400904

Reference yield:

Bis-(2-benzyloxy-5-formyl-phenyl)-iodonium; bromide (77251-51-5) → C60H65Br5N4O12Si (845784-24-9)

Guidance literature:

Multi-step reaction with 15 steps

1.1: imidazole; K₂CO₃ / dimethylformamide / 1 h / 20 °C

1.2: 96 percent / dimethylformamide / 6 h / 80 °C

2.1: 99 percent / piperidine; Ac₂O / tetrahydrofuran / 24 h / 80 °C

3.1: 86 percent / NaBH₄ / methanol; acetonitrile / 4 h / 0 - 20 °C

4.1: 88 percent / NaOMe; BuONO / methanol / 48 h / 0 °C

5.1: imidazole; K₂CO₃ / dimethylformamide / 0.5 h / 0 °C

5.2: 91 percent / dimethylformamide / 12 h / 0 - 20 °C

6.1: 99 percent / aq. HCl / tetrahydrofuran / 20 °C

7.1: 88 percent / imidazole / dimethylformamide / 11 h / 0 - 20 °C

8.1: TEMPO; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

9.1: pyridine / ethanol / 20 °C

10.1: 24 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

11.1: 97 percent / TEMPO; aq. KBr; NaOCl / NaHCO₃ / acetonitrile / 2 h / 0 °C

12.1: 94 percent / TFA; pentamethylbenzene / 2.5 h / 0 - 20 °C

13.1: 100 percent / NBS / acetonitrile / 1 h / 0 °C

14.1: CoCl₂*6H₂O; NaBH₄ / methanol / 0 °C

14.2: i-Pr₂NEt; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂; dimethylformamide / 0 - 20 °C

15.1: 78 percent / N-bromosuccinimide / acetonitrile / 2 h / 0 °C

With piperidine; pyridine; 1H-imidazole; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium tetrahydroborate; N-Bromosuccinimide; n-Butyl nitrite; pentamethylbenzene,; tetrabutyl ammonium fluoride; sodium methylate; acetic anhydride; potassium carbonate; trifluoroacetic acid; cobalt(II) chloride; potassium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.1: Knoevenagel condensation;

DOI:10.1002/chem.200400904

Reference yield:

4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzaldehyde (705932-29-2) → C60H65Br5N4O12Si (845784-24-9)

Guidance literature:

Multi-step reaction with 14 steps

1.1: 99 percent / piperidine; Ac₂O / tetrahydrofuran / 24 h / 80 °C

2.1: 86 percent / NaBH₄ / methanol; acetonitrile / 4 h / 0 - 20 °C

3.1: 88 percent / NaOMe; BuONO / methanol / 48 h / 0 °C

4.1: imidazole; K₂CO₃ / dimethylformamide / 0.5 h / 0 °C

4.2: 91 percent / dimethylformamide / 12 h / 0 - 20 °C

5.1: 99 percent / aq. HCl / tetrahydrofuran / 20 °C

6.1: 88 percent / imidazole / dimethylformamide / 11 h / 0 - 20 °C

7.1: TEMPO; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

8.1: pyridine / ethanol / 20 °C

9.1: 24 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

10.1: 97 percent / TEMPO; aq. KBr; NaOCl / NaHCO₃ / acetonitrile / 2 h / 0 °C

11.1: 94 percent / TFA; pentamethylbenzene / 2.5 h / 0 - 20 °C

12.1: 100 percent / NBS / acetonitrile / 1 h / 0 °C

13.1: CoCl₂*6H₂O; NaBH₄ / methanol / 0 °C

13.2: i-Pr₂NEt; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂; dimethylformamide / 0 - 20 °C

14.1: 78 percent / N-bromosuccinimide / acetonitrile / 2 h / 0 °C

With piperidine; pyridine; 1H-imidazole; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium tetrahydroborate; N-Bromosuccinimide; n-Butyl nitrite; pentamethylbenzene,; tetrabutyl ammonium fluoride; sodium methylate; acetic anhydride; potassium carbonate; trifluoroacetic acid; cobalt(II) chloride; potassium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Knoevenagel condensation;

DOI:10.1002/chem.200400904

upstream raw materials:

C₆₀H₆₆Br₄N₄O₁₂Si

4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzaldehyde

2-{4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzylidene}-malonic acid dimethyl ester

2-{4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzyl}-malonic acid dimethyl ester

Downstream raw materials:

C₄₈H₃₉Br₅N₄O₉