4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one

Base Information

Chemical Name:4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one
CAS No.:73755-85-8
Molecular Formula:C₂₈H₂₉F₂N₅O
Molecular Weight:489.568
Hs Code.:

Synonyms:4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one

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Chemical Property of 4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one

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Technology Process of 4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one

There total 7 articles about 4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: Methanesulfonic acid 4-(4-fluoro-phenyl)-4-oxo-butyl ester

: 75979-00-9
3-<(4-fluorophenyl)methyl>-N-(4-piperidinyl)-3H-imidazo<4,5-b>pyridin-2-amine

: 73755-85-8
4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 20h;
DOI:10.1021/jm00150a030

Reference yield:

: 73733-74-1
N-<(4-fluorophenyl)methyl>-3-nitro-2-pyridinamine

: 73755-85-8
4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / RaNi / methanol / 760 Torr / Ambient temperature

2: 54 percent / methanol / 2 h / Heating

3: 88 percent / yellow mercury oxide, sulfur / tetrahydrofuran / 3 h / Heating

4: 48 percent aq. HBr / 24 h / 70 °C

5: 10 percent / sodium carbonate / dimethylformamide / 20 h / 70 °C

With hydrogen bromide; hydrogen; sodium carbonate; sulfur; mercury(II) oxide; RaNi; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a030

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 73755-85-8
4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / sodium carbonate / dimethylformamide / 1 h / 90 °C

2: 100 percent / H₂ / RaNi / methanol / 760 Torr / Ambient temperature

3: 54 percent / methanol / 2 h / Heating

4: 88 percent / yellow mercury oxide, sulfur / tetrahydrofuran / 3 h / Heating

5: 48 percent aq. HBr / 24 h / 70 °C

6: 10 percent / sodium carbonate / dimethylformamide / 20 h / 70 °C

With hydrogen bromide; hydrogen; sodium carbonate; sulfur; mercury(II) oxide; RaNi; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a030