2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole

Base Information

• Chemical Name: 2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole
• CAS No.: 182059-80-9
• Molecular Formula: C₁₆H₁₅ClN₂O
• Molecular Weight: 286.761
• Mol file: 182059-80-9.mol

Synonyms:2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole

Chemical Property of 2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole

There total 1 articles about 2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-[2-(4-Chloro-phenyl)-1-methyl-1H-benzoimidazol-5-yl]-ethanone → 2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole (182059-80-9)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; In ethanol; for 3.3h;

DOI:10.1016/0223-5234(96)89560-2

Reference yield:

2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole (182059-80-9) → 2-(4-chlorophenyl)-5-ethyl-1-methyl-1H-benzimidazole

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 0.33 h / Ambient temperature

2: xylene / 7 h / Heating

3: 39 percent / H₂ / PtO₂ / ethanol / 0.67 h / 2378.9 Torr

With thionyl chloride; hydrogen; platinum(IV) oxide; In ethanol; dichloromethane; xylene;

DOI:10.1016/0223-5234(96)89560-2

Reference yield:

2-(4-chlorophenyl)-1-methyl-5-(1-hydroxyethyl)-1H-benzimidazole (182059-80-9) → 5-(1-Chloro-ethyl)-2-(4-chloro-phenyl)-1-methyl-1H-benzoimidazole; hydrochloride

Guidance literature:

With thionyl chloride; In dichloromethane; for 0.333333h; Ambient temperature;

DOI:10.1016/0223-5234(96)89560-2

Downstream raw materials:

2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-benzimidazole