1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine

Base Information

Chemical Name:1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine
CAS No.:1570496-82-0
Molecular Formula:C₂₄H₂₄F₃N₇O₂
Molecular Weight:499.495
Hs Code.:

Synonyms:1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine

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Chemical Property of 1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine

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Technology Process of 1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine

There total 6 articles about 1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1570496-95-5
2-(1-((2-chloropyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)oxazole

: 1570496-82-0
1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: In dimethyl sulfoxide; at 140 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1570496-88-6
ethyl 5-(4-(trifluoromethoxy)phenyl)oxazole-2-carboxylate

: 1570496-82-0
1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 16 h / 20 °C

2: sodium hydroxide / tetrahydrofuran / 16 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

4: dimethyl sulfoxide / 16 h / 140 °C / Inert atmosphere

With caesium carbonate; hydrazine hydrate; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1092390-14-1
2-amino-1-((4-trifluoromethoxy)phenyl)ethanone hydrochloride

: 1570496-82-0
1-methyl-4-{4-[(5-methyl-3-{5-[4-(trifluoromethoxy)phenyl]-1,3-oxazol-2-yl}-1H-1,2,4-triazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: trichlorophosphate / 3 h / 110 °C

3: hydrazine hydrate / ethanol / 16 h / 20 °C

4: sodium hydroxide / tetrahydrofuran / 16 h / Reflux

5: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

6: dimethyl sulfoxide / 16 h / 140 °C / Inert atmosphere

With caesium carbonate; hydrazine hydrate; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;