3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile

Base Information

Chemical Name:3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile
CAS No.:1188267-46-0
Molecular Formula:C₂₄H₂₁F₃N₂O₃
Molecular Weight:442.438
Hs Code.:

Synonyms:3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile

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Chemical Property of 3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile

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Technology Process of 3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile

There total 10 articles about 3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188267-18-6
1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexane-carbonitrile

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1188267-46-0
3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile

Guidance literature:: With triethylamine; In benzene; at 20 - 110 ℃; Inert atmosphere;

Reference yield:

: 1188267-41-5
3-(2-bromo-4-trifluoromethyl-phenoxy)-4-methoxy-benzaldehyde

: 1188267-46-0
3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 7 h / 130 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: Saturated solution

3.1: thionyl chloride / dichloromethane / 20 °C / Inert atmosphere; Cooling

4.1: N,N-dimethyl-formamide / 2 h / 20 °C

5.1: N-benzyl-trimethylammonium hydroxide / acetonitrile / 20 - 85 °C

6.1: sodium hydride / 1,2-dimethoxyethane / 2.33 h / 20 °C / Inert atmosphere

7.1: sodium chloride / water; dimethyl sulfoxide / 5 h / 140 °C

8.1: triethylamine / benzene / 20 - 110 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; N-benzyl-trimethylammonium hydroxide; sodium hydride; sodium carbonate; triethylamine; sodium chloride; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; benzene;

Reference yield:

: 68322-84-9
2-bromo-1-fluoro-4-(trifluoromethyl)benzene

: 1188267-46-0
3-dimethylaminomethylene-1-(4-methoxy-8-trifluoromethyl-dibenzofuran-1-yl)-4-oxo-cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5.25 h / 20 - 140 °C / Inert atmosphere

2.1: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 7 h / 130 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: Saturated solution

4.1: thionyl chloride / dichloromethane / 20 °C / Inert atmosphere; Cooling

5.1: N,N-dimethyl-formamide / 2 h / 20 °C

6.1: N-benzyl-trimethylammonium hydroxide / acetonitrile / 20 - 85 °C

7.1: sodium hydride / 1,2-dimethoxyethane / 2.33 h / 20 °C / Inert atmosphere

8.1: sodium chloride / water; dimethyl sulfoxide / 5 h / 140 °C

9.1: triethylamine / benzene / 20 - 110 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; N-benzyl-trimethylammonium hydroxide; sodium hydride; sodium carbonate; potassium carbonate; triethylamine; sodium chloride; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; benzene;