C₂₃H₂₂ClN₃O₃

Base Information

Chemical Name:C₂₃H₂₂ClN₃O₃
CAS No.:757248-23-0
Molecular Formula:C₂₃H₂₂ClN₃O₃
Molecular Weight:423.899
Hs Code.:

C<sub>23</sub>H<sub>22</sub>ClN<sub>3</sub>O<sub>3</sub>

Synonyms:C₂₃H₂₂ClN₃O₃

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Chemical Property of C₂₃H₂₂ClN₃O₃

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Technology Process of C₂₃H₂₂ClN₃O₃

There total 14 articles about C₂₃H₂₂ClN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 757247-59-9
2-chloro-4-((1S,7S,7aR)-1-ethyl-7-hydroxy-3-oxo-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-3-methylbenzonitrile

: 65-85-0,8013-63-6
benzoic acid

: 757248-23-0
C₂₃H₂₂ClN₃O₃

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm070312d

Reference yield:

: 573768-09-9
4-amino-2-chloro-3-methyl-benzonitrile

: 757248-23-0
C₂₃H₂₂ClN₃O₃

Guidance literature:: Multi-step reaction with 6 steps

1: 39 percent / CuI; tert-butylnitrite / acetonitrile / 3 h / 65 °C

2: 21 percent / Cs₂CO₃ / Pd₂(dba)3; chiral ferrocenyl catalyst / toluene; dimethylsulfoxide / 48 h / 100 °C

3: TFA / CH₂Cl₂ / 3 h / 20 °C

4: 130 mg / i-Pr₂NEt / tetrahydrofuran; toluene / 1.17 h / 0 - 20 °C

5: 68 percent / Bu₄NF / tetrahydrofuran / 1 h / 20 °C

6: 94 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; tert.-butylnitrite; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; chiral ferrocenyl catalyst; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile; 6: Mitsunobu reaction;
DOI:10.1021/jm070312d

Reference yield:

: 627531-48-0
N-(3-chloro-4-cyano-2-methylphenyl)acetamide

: 757248-23-0
C₂₃H₂₂ClN₃O₃

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / conc. HCl; EtOH / 0.5 h / Heating

2: 39 percent / CuI; tert-butylnitrite / acetonitrile / 3 h / 65 °C

3: 21 percent / Cs₂CO₃ / Pd₂(dba)3; chiral ferrocenyl catalyst / toluene; dimethylsulfoxide / 48 h / 100 °C

4: TFA / CH₂Cl₂ / 3 h / 20 °C

5: 130 mg / i-Pr₂NEt / tetrahydrofuran; toluene / 1.17 h / 0 - 20 °C

6: 68 percent / Bu₄NF / tetrahydrofuran / 1 h / 20 °C

7: 94 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; copper(l) iodide; tert.-butylnitrite; ethanol; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; chiral ferrocenyl catalyst; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile; 7: Mitsunobu reaction;
DOI:10.1021/jm070312d