(E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

Base Information

• Chemical Name: (E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid
• CAS No.: 1616119-03-9
• Molecular Formula: C₂₂H₂₄N₂O₆
• Molecular Weight: 412.442
• Mol file: 1616119-03-9.mol

Synonyms:(E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

Chemical Property of (E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid

There total 5 articles about (E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

(E)-ethyl 2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate (1616119-34-6) → (E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid (1616119-03-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃;

DOI:10.1016/j.bmc.2014.05.011

Reference yield:

(2-((2-(ethoxycarbonyl)cyclohex-1-en-1-yl)amino)-2-oxoethyl)triphenylphosphonium bromide (1616119-21-1) → (E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid (1616119-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide / 2 h / 20 °C

2: sodium hydroxide / methanol; tetrahydrofuran / 50 °C

With potassium tert-butylate; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; 1: |Wittig Olefination;

DOI:10.1016/j.bmc.2014.05.011

Reference yield:

ethyl 2-(2-bromoacetamido)cyclohex-1-enecarboxylate (1616119-20-0) → (E)-2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylic acid (1616119-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene / 3 h / Reflux

2: potassium tert-butylate / dimethyl sulfoxide / 2 h / 20 °C

3: sodium hydroxide / methanol; tetrahydrofuran / 50 °C

With potassium tert-butylate; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; benzene; 2: |Wittig Olefination;

DOI:10.1016/j.bmc.2014.05.011

upstream raw materials:

ethyl 2-(2-bromoacetamido)cyclohex-1-enecarboxylate

(2-((2-(ethoxycarbonyl)cyclohex-1-en-1-yl)amino)-2-oxoethyl)triphenylphosphonium bromide

ethyl 2-oxocyclohexane carboxylate

(E)-ethyl 2-(3-(5,6,7-trimethoxyquinolin-2-yl)acrylamido)cyclohex-1-enecarboxylate