Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie...

Base Information

• Chemical Name: Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie...
• CAS No.: 129245-53-0
• Molecular Formula: C₄₆H₈₀O₉Si₂
• Molecular Weight: 833.307

Synonyms:Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie...

Chemical Property of Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie...

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Technology Process of Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie...

There total 26 articles about Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Trimethylsilyl)ethanol (2916-68-9) → Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie... (129245-53-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / DMAP, DCC / CH₂Cl₂ / 16 h / Ambient temperature

2: 95 percent / O₂, tetraphenylporphyrin / CH₂Cl₂; methanol / 0.33 h / -78 °C / Irradiation

3: lithium hexamethyldisilazide / tetrahydrofuran / 1.) -78 deg C to -15 deg C, 1 h, 2.) -15 deg C, 1 h

4: 2.) I₂ / 1.) ether, 2.) C₆H₆, 8 h, sunlight

With dmap; iodine; oxygen; 5,15,10,20-tetraphenylporphyrin; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/a605894i

Reference yield:

(1R,4S,6S)-6-Hydroxy-4-methoxy-3-methyl-6-(2-trimethylsilyl-3-furyl)cyclohex-2-enecarboxylic acid (129245-45-0) → Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie... (129245-53-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / DMAP, DCC / CH₂Cl₂ / 16 h / Ambient temperature

2: 95 percent / O₂, tetraphenylporphyrin / CH₂Cl₂; methanol / 0.33 h / -78 °C / Irradiation

3: lithium hexamethyldisilazide / tetrahydrofuran / 1.) -78 deg C to -15 deg C, 1 h, 2.) -15 deg C, 1 h

4: 2.) I₂ / 1.) ether, 2.) C₆H₆, 8 h, sunlight

With dmap; iodine; oxygen; 5,15,10,20-tetraphenylporphyrin; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/a605894i

Reference yield:

2-Trimethylsilyl (1R,4S,6S)-6-hydroxy-4-methoxy-3-methyl-6-(2-trimethylsilyl-3-furyl)cyclohex-2-enecarboxylate (129285-24-1) → Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie... (129245-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / O₂, tetraphenylporphyrin / CH₂Cl₂; methanol / 0.33 h / -78 °C / Irradiation

2: lithium hexamethyldisilazide / tetrahydrofuran / 1.) -78 deg C to -15 deg C, 1 h, 2.) -15 deg C, 1 h

3: 2.) I₂ / 1.) ether, 2.) C₆H₆, 8 h, sunlight

With iodine; oxygen; 5,15,10,20-tetraphenylporphyrin; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/a605894i

upstream raw materials:

diazomethane

2-(Trimethylsilyl)ethanol

(1R,4S,6S)-6-Hydroxy-4-methoxy-3-methyl-6-(2-trimethylsilyl-3-furyl)cyclohex-2-enecarboxylic acid

2-Trimethylsilylethyl (1R,4S,6S)-6-hydroxy-6-(5-hydroxy-2-oxo-1-oxacyclopent-3-en-3-yl)-4-methoxy-3-methylcyclohex-2-enecarboxylate

Downstream raw materials:

(1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

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