ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate

Base Information

Chemical Name:ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate
CAS No.:1427035-39-9
Molecular Formula:C₁₉H₁₅BrClFN₂O₄
Molecular Weight:469.695
Hs Code.:

Synonyms:ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate

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Chemical Property of ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate

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Technology Process of ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate

There total 1 articles about ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1333340-15-0
ethyl 6-amino-5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate

: 627-11-2
2-Chloroethyl chloroformate

: 1427035-39-9
ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield: 45.0%

: 1427035-39-9
ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate

: 1333340-50-3
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(2-oxooxazolidin-3-yl)benzofuran-3-carboxamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 110 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1427035-39-9
ethyl 2-chloroethyl (5-bromo-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)carbamate

: 1427033-96-2
5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(2-oxooxazolidin-3-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 110 °C / Inert atmosphere

2: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; potassium iodide; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide;