(S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:87113-91-5
Molecular Formula:C₂₄H₃₁NO₃
Molecular Weight:381.515
Hs Code.:

Synonyms:(S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of (S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of (S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester

There total 2 articles about (S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 4942-47-6
(adamant-1-yl)-acetic acid

: 87113-91-5
(S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With N-Ethylmaleimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jm00369a017

Reference yield: 48.0%

: 4942-47-6
(adamant-1-yl)-acetic acid

: 41324-66-7
H-Pro-OBzl

: 96847-85-7
(S)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-isobutyl ester

: 87113-91-5
(S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: In acetonitrile; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2007.06.019

Reference yield:

: 87113-91-5
(S)-1-(2-adamantan-1-yl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester

: 87113-93-7
N-(1-adamantylacetyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

2: 88 percent / HOBt, NEM, DCC / tetrahydrofuran / pH 7.0-7.5

With N-Ethylmaleimide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00369a017