Boc-3-methyl-L-phenylalanine

Base Information

Chemical Name:Boc-3-methyl-L-phenylalanine
CAS No.:114873-06-2
Molecular Formula:C15H21NO4
Molecular Weight:279.336
Hs Code.:2924299090
DSSTox Substance ID:DTXSID00921524
Wikidata:Q72450003
Mol file:114873-06-2.mol

Synonyms:114873-06-2;Boc-Phe(3-Me)-OH;Boc-3-methyl-L-phenylalanine;Boc-3-Methy-L-Phenylalanine;(S)-2-((tert-Butoxycarbonyl)amino)-3-(m-tolyl)propanoic acid;Boc-D-Phe(3-Me)-OH;(2S)-3-(3-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(3-methylphenyl)propanoic acid;SCHEMBL16423;DTXSID00921524;HBBXWMALJNZDOM-LBPRGKRZSA-N;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-;MFCD01862944;AKOS015836522;AKOS015895346;AC-9924;AM83421;CS-W012282;AS-14666;Boc-Phe(3-Me)-OH, >=98.0% (TLC);3-methyl-N-(t-butoxycarbonyl)-L-phenylalanine;A50146;N-tert-Butoxycarbonyl-L-3-Methyl Phenylalanine;EN300-2010696;N-(tert-butoxycarbonyl)-3-methyl-L-phenylalanine;Boc-L-3-methylphenylalanine (Boc-L-Phe(3-Me)-OH);J-003145;(S)-2-(tert-butoxycarbonylamino)-3-m-tolylpropanoic acid;N-[tert-Butoxy(hydroxy)methylidene]-3-methylphenylalanine

Suppliers and Price of Boc-3-methyl-L-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Boc-3-methyl-L-phenylalanine
1g
$ 369.00

Usbiological
Boc-3-methyl-L-phenylalanine, 98.0 +%
1g
$ 200.00

TRC
Boc-3-Methyl-L-phenylalanine
50mg
$ 45.00

TRC
Boc-3-Methyl-L-phenylalanine
100mg
$ 60.00

TRC
Boc-3-Methyl-L-phenylalanine
500mg
$ 90.00

SynQuest Laboratories
3-Methyl-L-phenylalanine, N-Boc protected
5 g
$ 384.00

SynQuest Laboratories
3-Methyl-L-phenylalanine, N-Boc protected
1 g
$ 138.00

Sigma-Aldrich
Boc-Phe(3-Me)-OH ≥98.0% (TLC)
1g
$ 69.00

Matrix Scientific
Boc-3-methyl-L-phenylalanine
5g
$ 393.00

Matrix Scientific
Boc-3-methyl-L-phenylalanine
1g
$ 107.00

Total 58 raw suppliers

Chemical Property of Boc-3-methyl-L-phenylalanine

Chemical Property:

Vapor Pressure:1.62E-08mmHg at 25°C
Melting Point:70 °C
Refractive Index:1.526
Boiling Point:439.9 °C at 760 mmHg
PKA:3.92±0.10(Predicted)
Flash Point:219.9 °C
PSA：75.63000
Density:1.14 g/cm³
LogP:2.90630
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:279.14705815
Heavy Atom Count:20
Complexity:348

Purity/Quality:

97% ^*data from raw suppliers

Boc-3-methyl-L-phenylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC=C1)CC(C(=O)O)NC(=O)OC(C)(C)C
Isomeric SMILES:CC1=CC(=CC=C1)C[C@@H](C(=O)O)NC(=O)OC(C)(C)C

Technology Process of Boc-3-methyl-L-phenylalanine

There total 4 articles about Boc-3-methyl-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 2283-42-3
(S)-2-amino-3-(3-methylphenyl)propionic acid

: 114873-06-2
(S)-2-((tert-butoxycarbonyl)amino)-3-(m-tolyl)propanoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 18h;

Reference yield:

: 2-tert-butoxycarbonylamino-2-(3-methyl-benzyl)-malonic acid diethyl ester

: 114873-06-2
(S)-2-((tert-butoxycarbonyl)amino)-3-(m-tolyl)propanoic acid

Guidance literature:: 2-tert-butoxycarbonylamino-2-(3-methyl-benzyl)-malonic acid diethyl ester; With acetic acid; for 16h; pH=5; Heating;

With alcalase 2.4L; sodium hydrogencarbonate; at 25 - 27 ℃; for 2.5h; Further stages.;
DOI:10.1021/jm010206q

Reference yield:

: 620-13-3
1-bromomethyl-3-methyl-benzene

: 114873-06-2
(S)-2-((tert-butoxycarbonyl)amino)-3-(m-tolyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide; hexane / 2 h / 20 °C

1.2: dimethylformamide; hexane / 2 h / 20 °C

2.1: aq. AcOH / 16 h / pH 5 / Heating

2.2: 3.55 g / Alcalase 2.4L; aq. NaHCO₃ / 2.5 h / 25 - 27 °C

With sodium hydride; acetic acid; In hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm010206q