(S)-1-N-Boc-2-Methylpiperazine

Base Information Edit

Chemical Name:(S)-1-N-Boc-2-Methylpiperazine
CAS No.:169447-70-5
Molecular Formula:C10H20N2O2
Molecular Weight:200.281
Hs Code.:2933599090
European Community (EC) Number:629-890-4
DSSTox Substance ID:DTXSID80435290
Nikkaji Number:J674.086C
Wikidata:Q72450026
Mol file:169447-70-5.mol

Synonyms:169447-70-5;(S)-1-N-Boc-2-Methylpiperazine;(S)-1-Boc-2-methylpiperazine;(S)-1-BOC-2-METHYL-PIPERAZINE;Tert-butyl (2S)-2-methylpiperazine-1-carboxylate;(S)-tert-butyl 2-methylpiperazine-1-carboxylate;S-1-N-Boc-2-methylpiperazine;MFCD01862121;1-PIPERAZINECARBOXYLIC ACID, 2-METHYL-, 1,1-DIMETHYLETHYL ESTER, (2S)-;(S)-2-Methyl-piperazine-1-carboxylic acid tert-butyl ester;(S)-1-N-Boc-2-methyl piperazine;SCHEMBL102292;DTXSID80435290;DATRVIMZZZVHMP-QMMMGPOBSA-N;(S)-N1-Boc-2-methyl-piperazine;BCP11308;CS-D0650;AKOS005258531;AC-2192;AS-36949;(s)-t-butyl-2-methylpiperazin-1-carboxylate;A3740;AM20090017;B4846;(S)-1-N-Boc-2-methylpiperazine, AldrichCPR;(S)-tert-butyl 2-methylpiperazin-1-carboxylate;EN300-159795;(S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine;tert-Butyl (S)-2-Methyl-1-piperazinecarboxylate;tert-butyl(2S)-2-methylpiperazine-1-carboxylate;1-dimethylethyl (2s)-2-methyl-1-piperazinecarboxylate;1,1-dimethylethyl(2s)-2-methyl-1-piperazinecarboxylate;(2S)-2-Methyl-1-piperazinecarboxylic acid tert-butyl ester;(S)-2-Methyl-1-piperazinecarboxylic Acid tert-Butyl Ester;(S)-2-methylpiperazine-1-carboxylic acid, tert-butyl ester;1,1-Dimethylethyl (2S)-2-methyl-1-piperazinecarboxylate;2-(S)-Methyl-piperazine-1-carboxylic acid tert-butyl ester;(2S)-2-methyl-1-piperazinecarboxylic acid-1,1-dimethylethyl ester

Suppliers and Price of (S)-1-N-Boc-2-Methylpiperazine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-1-Boc-2-methylpiperazine
10g
$ 970.00

TCI Chemical
(S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine >98.0%(GC)(T)
5g
$ 148.00

TCI Chemical
(S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine >98.0%(GC)(T)
1g
$ 45.00

SynQuest Laboratories
(2S)-2-Methylpiperazine, N1-Boc protected 98.0%
1 g
$ 18.00

Matrix Scientific
(S)-1-Boc-2-Methylpiperazine 98%
5g
$ 61.00

Matrix Scientific
(S)-1-Boc-2-Methylpiperazine 98%
1g
$ 23.00

J&W Pharmlab
(S)-1-Boc-2-methyl-piperazine 96%
5g
$ 40.00

J&W Pharmlab
(S)-1-Boc-2-methyl-piperazine 96%
100g
$ 398.00

J&W Pharmlab
(S)-1-Boc-2-methyl-piperazine 96%
25g
$ 130.00

Crysdot
(S)-tert-Butyl2-methylpiperazine-1-carboxylate 98%
100g
$ 356.00

Total 115 raw suppliers

Chemical Property of (S)-1-N-Boc-2-Methylpiperazine Edit

Chemical Property:

Vapor Pressure:0.008mmHg at 25°C
Melting Point:43.0 to 47.0 °C
Refractive Index:1.459
Boiling Point:268.74 °C at 760 mmHg
PKA:8.49±0.40(Predicted)
Flash Point:116.33 °C
PSA：41.57000
Density:0.998 g/cm³
LogP:1.48190
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Solubility.:soluble in Methanol
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:200.152477885
Heavy Atom Count:14
Complexity:211

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-Boc-2-methylpiperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CNCCN1C(=O)OC(C)(C)C
Isomeric SMILES:C[C@H]1CNCCN1C(=O)OC(C)(C)C
Uses (S)-1-N-Boc-2-methylpiperazine is used in the preparation of pyrazolo[3,4-b]pyridine dual pharmacophores as PDE4-muscarinic antagonists. Used in the preparation of pyrazolo[3,4-b]pyridine dual pharmacophores as PDE4-muscarinic antagonists.

Technology Process of (S)-1-N-Boc-2-Methylpiperazine

There total 13 articles about (S)-1-N-Boc-2-Methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 169447-69-2
tert-Butyl (S)-2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate

: 169447-70-5
(S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; Ambient temperature;
DOI:10.1021/jo00118a039

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 169447-70-5
(S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: (S)-2-methylpiperazine; With n-butyllithium; In tetrahydrofuran; at 20 ℃; for 0.5h;

With tert-butyldimethylsilyl chloride; In tetrahydrofuran; for 1h;

di-tert-butyl dicarbonate; In tetrahydrofuran; for 1h;