2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide

Base Information

• Chemical Name: 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide
• CAS No.: 1360180-57-9
• Molecular Formula: C₂₅H₂₁N₅O₃S₂
• Molecular Weight: 503.605

Synonyms:2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide

Chemical Property of 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide

Chemical Property:

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Technology Process of 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide

There total 4 articles about 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-(prop-2-ynyloxy)phenyl)acetamide (1360180-33-1) + azidomethyl phenyl sulphide (77422-70-9) → 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide (1360180-57-9)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 - 40 ℃;

DOI:10.1016/j.bmc.2011.12.047

Reference yield:

(3-prop-2-ynoxyphenyl)ammonium chloride (60042-20-8) → 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide (1360180-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Reflux

1.2: 20 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 - 40 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1016/j.bmc.2011.12.047

Reference yield:

2-(3-Oxo-3h-benzo[d]isothiazol-2-yl)-acetic acid (82152-06-5) → 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-((1-(phenylthiomethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide (1360180-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Reflux

1.2: 20 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 - 40 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1016/j.bmc.2011.12.047

upstream raw materials:

(3-prop-2-ynoxyphenyl)ammonium chloride

2-(3-oxobenzo[d]isothiazol-2(3H)-yl)-N-(3-(prop-2-ynyloxy)phenyl)acetamide

azidomethyl phenyl sulphide

2-(3-Oxo-3h-benzo[d]isothiazol-2-yl)-acetic acid

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