(4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole

Base Information

Chemical Name:(4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole
CAS No.:938448-97-6
Molecular Formula:C₁₉H₁₈ClNO
Molecular Weight:311.811
Hs Code.:

Synonyms:(4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole

Suppliers and Price of (4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole

There total 3 articles about (4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 938448-93-2
(E)-3-[(4S,5S)-4-benzyl-4,5-dihydro-2-phenyloxazol-5-yl]prop-2-en-1-ol

: 938448-97-6
(4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole

Guidance literature:: With dmap; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/ejoc.200600927

Reference yield:

: 938448-89-6
methyl (E)-3-[(4S,5S)-4-benzyl-4,5-dihydro-2-phenyloxazol-5-yl]acrylate

: 938448-97-6
(4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / i-Bu₂AlH / tetrahydrofuran; hexane / 2 h / -78 °C

2: 86 percent / p-toluenesulfonyl chloride; 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h / 20 °C

With dmap; diisobutylaluminium hydride; p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/ejoc.200600927

Reference yield:

: 208935-28-8
(4S-trans)-4,5-dihydro-4-benzyl-2-phenyl-5-vinyloxazoline

: 938448-97-6
(4S,5S)-4-benzyl-5-[(E)-3-chloroprop-1-enyl]-4,5-dihydro-2-phenyloxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: ozone / methanol / -78 °C

1.2: 80 percent / LiCl; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h

2.1: 93 percent / i-Bu₂AlH / tetrahydrofuran; hexane / 2 h / -78 °C

3.1: 86 percent / p-toluenesulfonyl chloride; 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h / 20 °C

With dmap; diisobutylaluminium hydride; ozone; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1002/ejoc.200600927