2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone

Base Information

Chemical Name:2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone
CAS No.:1194285-57-8
Molecular Formula:C₂₀H₁₆ClF₃N₂OS
Molecular Weight:424.874
Hs Code.:

Synonyms:2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone

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Chemical Property of 2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone

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Technology Process of 2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone

There total 4 articles about 2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1456735-43-5
2-[3-(4-chlorobenzoyl)-4-(N-methyl-N-(4-trifluoromethylphenyl)-aminomethyl)-thiophen-2-yl]-isoindole-1,3-dione

: 1194285-57-8
2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2013.07.002

Reference yield:

: 1456735-16-2
2-[5-bromo-3-(4-chlorobenzoyl)-4-(N-methyl-N-(4-trifluoromethylphenyl)-aminomethyl)-thiophen-2-yl]-isoindole-1,3-dione

: 1194285-57-8
2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 3 h / 20 °C / 3102.97 Torr / Inert atmosphere

2: hydrazine hydrate / ethanol / 1 h / Inert atmosphere; Reflux

With palladium 10% on activated carbon; hydrogen; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.07.002

Reference yield:

: 1027493-30-6
2-[5-bromo-4-bromomethyl-3-(4-chloro-benzoyl)-thiophen-2-yl]-isoindole-1,3-dione

: 1194285-57-8
2-amino-4-((N-methyl-N-(4-(trifluoromethyl)phenylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 1 h / 60 °C

2: triethylamine; palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 3 h / 20 °C / 3102.97 Torr / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / Inert atmosphere; Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2013.07.002