(S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime

Base Information

• Chemical Name: (S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime
• CAS No.: 260998-34-3
• Molecular Formula: C₂₁H₂₁NO
• Molecular Weight: 303.404
• Mol file: 260998-34-3.mol

Synonyms:(S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime

Chemical Property of (S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime

There total 1 articles about (S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

β-naphthaldehyde (66-99-9) + (S)-(-)-N-(1-phenylbutoxy)phthalimide (185758-21-8) → (S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime (260998-34-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃;

DOI:10.1039/a907186e

Reference yield: 50.0%

n-butyllithium (109-72-8,29786-93-4) + (S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime (260998-34-3) → (S)-1-(2-Naphthyl)-N-[(S)-1-phenylbutoxy]pentylamine (260998-53-6)

Guidance literature:

(S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime; With boron trifluoride diethyl etherate; In diethyl ether; toluene; at -78 ℃; for 0.25h;

n-butyllithium; In diethyl ether; toluene; at -78 ℃;

DOI:10.1039/a907186e

Reference yield:

(S)-O-(1-Phenylbutyl)-2-naphthaldehyde oxime (260998-34-3) → (S)-(-)-N-Benzyloxycarbonyl-1-(2-naphthyl)pentylamine

Guidance literature:

Multi-step reaction with 3 steps

1.1: BF₃*Et₂O / toluene; diethyl ether / 0.25 h / -78 °C

1.2: 50 percent / toluene; diethyl ether / -78 °C

2.1: Zn; AcOH; H₂O / 50 °C / sonication

3.1: K₂CO₃ / tetrahydrofuran; H₂O / 1 h / 20 °C

With boron trifluoride diethyl etherate; water; potassium carbonate; acetic acid; zinc; In tetrahydrofuran; diethyl ether; water; toluene; 1.1: Complexation / 1.2: Addition / 2.1: Reduction / 3.1: Acylation;

DOI:10.1039/a907186e

upstream raw materials:

β-naphthaldehyde

(S)-(-)-N-(1-phenylbutoxy)phthalimide

Downstream raw materials:

(S)-1-(2-Naphthyl)-N-[(S)-1-phenylbutoxy]pentylamine