4-(2-Bromoacetyl)-2,6-dimethoxyphenyl acetate

Base Information

• Chemical Name: 4-(2-Bromoacetyl)-2,6-dimethoxyphenyl acetate
• CAS No.: 28294-48-6
• Molecular Formula: C₁₂H₁₃BrO₅
• Molecular Weight: 317.136
• Hs Code.: 2915390090
• Mol file: 28294-48-6.mol

Synonyms:Acetophenone,2-bromo-4'-hydroxy-3',5'-dimethoxy-, acetate (8CI);4-(Bromoacetyl)-2,6-dimethoxyphenyl acetate;4-Acetoxy-3,5-dimethoxy-a-bromoacetophenone;4-Acetoxy-a-bromo-3,5-dimethoxyacetophenone;w-Bromo-4-acetoxy-3,5-dimethoxyacetophenone;

Chemical Property of 4-(2-Bromoacetyl)-2,6-dimethoxyphenyl acetate

Chemical Property:

• Melting Point: 126-127 °C
• Refractive Index: 1.537
• Boiling Point: 349 °C at 760 mmHg
• Flash Point: 164.9 °C
• PSA: 61.83000
• Density: 1.442 g/cm³
• LogP: 2.20670

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Bromoacetyl)-2,6-dimethoxyphenylacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-Bromoacetyl)-2,6-dimethoxyphenyl acetate

There total 2 articles about 4-(2-Bromoacetyl)-2,6-dimethoxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

→ 4-(bromoacetyl)-2,6-dimethoxyphenyl acetate (28294-48-6)

Guidance literature:

Reference yield:

1-(4-acetoxy-3,5-dimethoxy-phenyl)-ethanone (28294-47-5) → 4-(bromoacetyl)-2,6-dimethoxyphenyl acetate (28294-48-6)

Guidance literature:

With bromine; In chloroform;

Reference yield:

4-(bromoacetyl)-2,6-dimethoxyphenyl acetate (28294-48-6) → 4-[(Z)-2-(2,6-Dimethoxy-4-methyl-phenoxy)-vinyl]-2,6-dimethoxy-phenol

Guidance literature:

Multi-step reaction with 5 steps

1: K₂CO₃, KI / acetone

2: K₂CO₃ / dimethylsulfoxide

3: LiAlH₄ / tetrahydrofuran

4: H₂ / Pd-C

5: aq. NaOH / 140 °C

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; dimethyl sulfoxide; acetone;

upstream raw materials:

1-(4-acetoxy-3,5-dimethoxy-phenyl)-ethanone

Downstream raw materials:

Acetic acid 4-[2-(2,6-dimethoxy-4-methyl-phenoxy)-acetyl]-2,6-dimethoxy-phenyl ester

Acetic acid 4-[2-(4-formyl-2,6-dimethoxy-phenoxy)-acetyl]-2,6-dimethoxy-phenyl ester

4-[2-(2,6-Dimethoxy-4-methyl-phenoxy)-1-hydroxy-ethyl]-2,6-dimethoxy-phenol

4-[1-Hydroxy-2-(4-hydroxymethyl-2,6-dimethoxy-phenoxy)-ethyl]-2,6-dimethoxy-phenol

Refernces

• 1、 -. "Derivatives of heterocycles with 5 members, their preparation and their use as medicaments". . . Retrieved 2008/06/13.