1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine

Base Information

• Chemical Name: 1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine
• CAS No.: 1338483-03-6
• Molecular Formula: C₁₆H₁₅NS
• Molecular Weight: 253.368

Synonyms:1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine

Chemical Property of 1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine

Chemical Property:

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Technology Process of 1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine

There total 7 articles about 1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(1-Azidoethyl)-3-phenylbenzo[b]thiophene (1393176-49-2) → 1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine (1338483-03-6)

Guidance literature:

2-(1-Azidoethyl)-3-phenylbenzo[b]thiophene; With triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;

With ammonia; In methanol;

Reference yield:

2-(1-(3-phenylbenzo[b]thiophen-2-yl)ethyl)isoindoline-1,3-dione (1338483-02-5) → 1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine (1338483-03-6)

Guidance literature:

With hydrazine hydrate; In ethanol; at 50 ℃; for 18h;

Reference yield:

acetyl-2 bromo-3 benzothiophene (99661-07-1) → 1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine (1338483-03-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / trans-bis(triphenylphosphine)palladium dichloride / toluene; water / 16 h / 110 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.08 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Cooling with ice

4: hydrazine hydrate / ethanol / 18 h / 50 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; sodium carbonate; hydrazine hydrate; triphenylphosphine; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; methanol; ethanol; water; toluene;

upstream raw materials:

1-(3-phenylbenzo[b]thiophen-2-yl)ethan-1-one

3-Bromothianaphthene

acetyl-2 bromo-3 benzothiophene

2-(1-(3-phenylbenzo[b]thiophen-2-yl)ethyl)isoindoline-1,3-dione

Downstream raw materials:

N-(1-(3-phenylbenzo[b]thiophen-2-yl)ethyl)-9H-purin-6-amine

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